First Female Prime Minister of Belgium: Wilmès made history in October 2019 when she became the first woman to serve as the Prime Minister of Belgium. She held this position until October 2020, leading the country during a challenging period marked by political uncertainty and the COVID-19 pandemic.

Leadership during the COVID-19 Crisis: As Prime Minister, Wilmès played a crucial role in managing the response to the COVID-19 pandemic in Belgium. She worked to coordinate the government's efforts to control the spread of the virus, ensure healthcare capacity, and mitigate the socio-economic impact of the crisis.

Crisis Management and Government Stability: Wilmès led the government during a period of political instability and managed to maintain stability despite the challenges of forming coalitions in a fragmented political landscape. Her leadership helped navigate the country through political transitions and maintain continuity in governance.

Fiscal Responsibility and Budgetary Measures: As Minister of Budget and Finance, Wilmès demonstrated a commitment to fiscal responsibility and implemented measures aimed at ensuring sound public finances. She played a role in formulating and implementing budgetary policies, managing public debt, and promoting economic stability.

International Engagement: Wilmès represented Belgium on the international stage and engaged in diplomatic efforts to strengthen relationships with other countries. She participated in high-level meetings, summits, and international forums, advocating for Belgian interests and collaborating on global challenges.